Invention Grant
![Substituted pyrrolo[3,4-d]imidazoles as MDM2-p53 inhibitors](/docs/US/2023-05-02/US11639355B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted pyrrolo[3,4-d]imidazoles as MDM2-p53 inhibitors
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Application No.: US16979202Application Date: 2019-03-12
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Publication No.: US11639355B2Publication Date: 2023-05-02
- Inventor: Kevin X Chen , Xiaobing Yan , Jianglei Huang , Yuekun Nie , Guoping Hu , Jian Li , Shuhui Chen , Jiaqiang Dong , Tie-Lin Wang
- Applicant: LUOXIN PHARMACEUTICAL (SHANGHAI) CO., LTD. , SHANDONG LUOXIN PHARMACEUTICAL GROUP STOCK CO., LTD. , MEDSHINE DISCOVERY INC.
- Applicant Address: CN Shanghai; CN Shandong; CN Jiangsu
- Assignee: LUOXIN PHARMACEUTICAL (SHANGHAI) CO., LTD.,SHANDONG LUOXIN PHARMACEUTICAL GROUP STOCK CO., LTD.,MEDSHINE DISCOVERY INC.
- Current Assignee: LUOXIN PHARMACEUTICAL (SHANGHAI) CO., LTD.,SHANDONG LUOXIN PHARMACEUTICAL GROUP STOCK CO., LTD.,MEDSHINE DISCOVERY INC.
- Current Assignee Address: CN Shanghai; CN Shandong; CN Jiangsu
- Agency: Houston Beshining Law Office PLLC
- Agent Liangang Ye
- Priority: CN201810201653.4 20180312,CN201811157824.4 20180930
- International Application: PCT/CN2019/077845 WO 20190312
- International Announcement: WO2019/174576 WO 20190919
- Main IPC: C07D239/22
- IPC: C07D239/22 ; C07D487/04 ; A61P35/00 ; C07D519/00
![Substituted pyrrolo[3,4-d]imidazoles as MDM2-p53 inhibitors](/abs-image/US/2023/05/02/US11639355B2/abs.jpg.150x150.jpg)
Abstract:
Disclosed is a novel class of MDM2-p53 inhibitor compounds having an imidaxopyrolone structure, and specifically disclosed are compounds represented by formulas (I-1) and (I-2) and pharmaceutically acceptable salts thereof.
Public/Granted literature
- US20210230164A1 IMIDAXOPYROLONE COMPOUND AND APPLICATION THEREOF Public/Granted day:2021-07-29
Information query
