- 专利标题： Modified bacterial protein expression system
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申请号： US16886156申请日： 2020-05-28
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公开(公告)号： US11624081B2公开(公告)日： 2023-04-11
- 发明人: Maxwell Gottesman
- 申请人： THE TRUSTESS OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 申请人地址： US NY New York
- 专利权人： THE TRUSTESS OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人： THE TRUSTESS OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人地址： US NY New York
- 主分类号： C12N9/52
- IPC分类号： C12N9/52 ; C12P21/02 ; C07K14/245 ; C12N15/10 ; C12N15/70
摘要：
The present disclosure provides host cells for reliable, high yield recombinant protein production, including unstable proteins. The present host cell (e.g., a bacterial cell) is deficient in at least one protease (or a subunit of a protease) such as Clp or ClpP. The host cell may also contain an expression vector that encodes a protein or polypeptide for overexpression.
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