Invention Grant
- Patent Title: Treatments for retinal disease
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Application No.: US17746443Application Date: 2022-05-17
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Publication No.: US11576983B2Publication Date: 2023-02-14
- Inventor: David H. Kirn , Melissa Kotterman , David Schaffer
- Applicant: 4D MOLECULAR THERAPEUTICS INC.
- Applicant Address: US CA Emeryville
- Assignee: 4D MOLECULAR THERAPEUTICS INC.
- Current Assignee: 4D MOLECULAR THERAPEUTICS INC.
- Current Assignee Address: US CA Emeryville
- Agency: Much Shelist, P.C.
- Agent Christopher M. Cabral
- Main IPC: C12N15/864
- IPC: C12N15/864 ; A61K48/00 ; A61P27/02 ; A61K9/00 ; C07K14/005 ; C12N15/86

Abstract:
Provided herein are variant adeno-associated virus (AAV) capsid proteins having one or more modifications in amino acid sequence relative to a parental AAV capsid protein, which, when present in an AAV virion, confer increased infectivity of one or more types of retinal cells as compared to the infectivity of the retinal cells by an AAV virion comprising the unmodified parental AAV capsid protein. Also provided are recombinant AAV virions and pharmaceutical compositions thereof comprising a variant AAV capsid protein as described herein, methods of making these rAAV capsid proteins and virions, and methods for using these rAAV capsid proteins and virions in research and clinical practice, for example in, e.g., the delivery of nucleic acid sequences to one or more ceils of the retina for the treatment of retinal disorders and diseases.
Public/Granted literature
- US20230001018A1 TREATMENTS FOR RETINAL DISEASE Public/Granted day:2023-01-05
Information query
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