A noise reduction circuit for a matrix LED driver includes a pseudo random number generator, an up counter, a clock module, and a plurality of matrix switch controllers. The matrix switch controllers and the up counter randomly change a power-on sequence applied across matrix switches in the matrix LED driver according to working random numbers generated by the pseudo random number generator. The circuit prevents jitter-induced noise from periodically reoccurring at the power source of the matrix LED driver, thereby reducing noise energy.