- 专利标题： Compounds and methods used in assessing mono-PARP activity
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申请号： US16715907申请日： 2019-12-16
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公开(公告)号： US11530235B2公开(公告)日： 2022-12-20
- 发明人: Michael Cohen , Ian Carter-O'Connell , Rory Morgan , Haihong Jin
- 申请人： Oregon Health & Science University
- 申请人地址： US OR Portland
- 专利权人： Oregon Health & Science University
- 当前专利权人： Oregon Health & Science University
- 当前专利权人地址： US OR Portland
- 代理机构： Lee & Hayes, P.C.
- 代理商 Tanya M. Harding; C. Rachal Winger
- 主分类号： C07H19/207
- IPC分类号： C07H19/207 ; C12N9/10 ; C12Q1/48 ; A61K38/00
摘要：
Mutant mono ADP-ribose-polymerases (mono-PARP) proteins and small molecule compound substrates specific for the mutant mono-PARP proteins as well as methods of using these compositions to identify protein targets of the mono-PARPs and to screen for antagonists of the mono-PARPs are described.
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