- 专利标题： Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same
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申请号： US15524578申请日： 2015-11-05
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公开(公告)号： US11529436B2公开(公告)日： 2022-12-20
- 发明人: Kelsey Nicole Retting , Colin M. O'Neill , Deborah Lynn Greene Nguyen , Sharon C. Presnell , Jessica Langer , Guive Balooch , Elizabeth Wu , Julien Demaude
- 申请人： Organovo, Inc. , L'Oreal
- 申请人地址： US CA San Diego; FR Paris
- 专利权人： Organovo, Inc.,L'Oreal
- 当前专利权人： Organovo, Inc.,L'Oreal
- 当前专利权人地址： US CA San Diego; FR Paris
- 代理机构： Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 国际申请： PCT/US2015/059327 WO 20151105
- 国际公布： WO2016/073782 WO 20160512
- 主分类号： A61L27/60
- IPC分类号： A61L27/60 ; A61L27/36 ; C12N5/071 ; A61L27/50 ; G01N33/50
摘要：
Disclosed are bioprinted, three-dimensional, biological skin tissues comprising: a dermal layer comprising dermal fibroblasts; and an epidermal layer comprising keratinocytes, the epidermal layer in contact with the dermal layer to form the three-dimensional, engineered, biological skin tissue. Also disclosed are arrays of engineered skin tissues and methods of making engineered skin tissues.
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