One variation of a method for assisting execution of manual protocols at production equipment includes: identifying a site occupied by a mobile device based on a geospatial location of a device; identifying a space within the building occupied by the device based on identifiers of a set of wireless access points wirelessly accessible to the device and known locations of wireless access points within the building; loading a protocol associated with an equipment unit in the space; calculating a position of the device within the space based on positions optical features, detected in a field of view of an optical sensor at the device, relative to reference features represented in a space model of the space; and, when the position of the device falls within a threshold distance of a reference location proximal the equipment unit defined in a step of the procedure, rendering guidance for the step.