A method of building an abnormality quantifier comprising: generating at least one selected first dataset comprising measurements of a normal population or sample and at least one second selected dataset comprising measurements of an abnormal population or sample; generating an image or map by imagizing the datasets; identifying a normality zone within the image or map using the first dataset; identifying an abnormality zone within the image or map using the second dataset; determining a definition of abnormality based on a comparison of the normality zone and the abnormality zone; receiving or accessing at least one third dataset comprising measurements of a both known normal and abnormal population or sample; testing the performance of the initially defined abnormality against one or more preset performance criteria; and outputting an abnormality quantifier when optimal performance has been reached.