- 专利标题: Ionizable lipidoids and their uses
-
申请号: US16556470申请日: 2019-08-30
-
公开(公告)号: US11459304B2公开(公告)日: 2022-10-04
- 发明人: Lei Miao , Linxian Li , Daniel Griffith Anderson , Yuxuan Huang
- 申请人: Massachusetts Institute of Technology
- 申请人地址: US MA Cambridge
- 专利权人: Massachusetts Institute of Technology
- 当前专利权人: Massachusetts Institute of Technology
- 当前专利权人地址: US MA Cambridge
- 代理机构: Wolf, Greenfield & Sacks, P.C.
- 主分类号: C07D233/40
- IPC分类号: C07D233/40 ; C07C251/08 ; A61K39/39 ; C07D403/06 ; C07C237/06 ; A61K39/00
摘要:
Provided herein are lipidoid compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, solvates, hydrates, polymorphs, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive lipidoid compounds, compositions, or formulations for treating and/or preventing diseases (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, metabolic disorder, long-term medical condition, inflammatory disease, autoinflammatory disease, liver disease, lung disease, spleen disease, familial amyloid neuropathy, cardiovascular disease, viral infection, infectious disease, fibrotic condition, or autoimmune disease) in a subject, methods for synthesizing the compounds described herein, and compounds described herein synthesized by the synthetic methods described herein. The compounds are effective carriers for the delivery of an agent such as a polynucleotide (e.g., RNA) to a cell.
信息查询