发明授权
- 专利标题: GPC3 and ASGPR1 double-targeted transgenic immune effector cell and use thereof
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申请号: US15532965申请日: 2015-11-30
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公开(公告)号: US11453860B2公开(公告)日: 2022-09-27
- 发明人: Huamao Wang , Xiumei Cai , Hongxia Zhao , Bo Song , Yuanmei Chen , Yinyu Zhu
- 申请人: CRAGE MEDICAL CO., LIMITED
- 申请人地址: HK Kowloon
- 专利权人: CRAGE MEDICAL CO., LIMITED
- 当前专利权人: CRAGE MEDICAL CO., LIMITED
- 当前专利权人地址: HK Kowloon
- 代理机构: Kilpatrick Townsend & Stockton LLP
- 优先权: CN201410736009.9 20141204
- 国际申请: PCT/CN2015/095938 WO 20151130
- 国际公布: WO2016/086813 WO 20160609
- 主分类号: C12N5/0783
- IPC分类号: C12N5/0783 ; C12N5/10 ; A61K39/395 ; C12N15/63 ; C07K14/00 ; C07K16/28 ; A61K35/17 ; A61P35/00 ; C07K14/725 ; C07K14/705 ; C07K16/30 ; C12N15/86 ; A61K39/00
摘要:
Provided are a GPC3 and ASGPR1 double-targeted transgenic immune effector cell and use thereof. The cell is an immune effector cell capable of identifying the gene modification of GPC3 and ASGPR1 simultaneously, and the cell can be used in the treatment of GPC3 and ASGPR1 double positive tumours, such as liver cancer.
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