Adapting a machine learning model to process data that differs from training data used to configure the model for a specified objective is described. A domain adaptation system trains the model to process new domain data that differs from a training data domain by using the model to generate a feature representation for the new domain data, which describes different content types included in the new domain data. The domain adaptation system then generates a probability distribution for each discrete region of the new domain data, which describes a likelihood of the region including different content described by the feature representation. The probability distribution is compared to ground truth information for the new domain data to determine a loss function, which is used to refine model parameters. After determining that model outputs achieve a threshold similarity to the ground truth information, the model is output as a domain-agnostic model.