An optical fingerprint sensing device includes optical sensing pixels, optical blocked pixels and a readout circuit. Each of the optical sensing pixels includes a first photodevice for sensing an illumination through an optical path. The optical sensing pixels are configured to generate sensing signals. Each of the optical blocked pixels includes a second photodevice blocked from the illumination. The optical sensing pixels are configured to generate a plurality of tracking signals. The readout circuit is configured to generate output signals according to differences between the sensing signals and the tracking signals.