![Process for producing a hydrate of a hydrochloride salt of 2,2′-((((((2-acetylnaphtho[2,3-b]furan-4,9-diyl)bis(oxy))bis(carbonyl))bis(azanediyl))bis(ethane-2,1-diyl))bis(azanediyl))diacetic acid](/docs/US/2022-08-16/US11414394B2/abs.jpg.600x600.jpg)
- 专利标题： Process for producing a hydrate of a hydrochloride salt of 2,2′-((((((2-acetylnaphtho[2,3-b]furan-4,9-diyl)bis(oxy))bis(carbonyl))bis(azanediyl))bis(ethane-2,1-diyl))bis(azanediyl))diacetic acid
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申请号： US17005597申请日： 2020-08-28
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公开(公告)号： US11414394B2公开(公告)日： 2022-08-16
- 发明人: Hitoshi Ban , Seiji Kamioka , Yusuke Sawayama , Chiang Jia Li
- 申请人： SUMITOMO PHARMA ONCOLOGY, INC. , SUMITOMO PHARMA CO., LTD.
- 申请人地址： US MA Cambridge; JP Osaka
- 专利权人： SUMITOMO PHARMA ONCOLOGY, INC.,SUMITOMO PHARMA CO., LTD.
- 当前专利权人： SUMITOMO PHARMA ONCOLOGY, INC.,SUMITOMO PHARMA CO., LTD.
- 当前专利权人地址： US MA Cambridge; JP Osaka
- 代理机构： Sughrue Mion, PLLC
- 主分类号： C07D307/92
- IPC分类号： C07D307/92 ; C07D405/14 ; C07D405/12 ; A61P35/02 ; A61P35/00
![Process for producing a hydrate of a hydrochloride salt of 2,2′-((((((2-acetylnaphtho[2,3-b]furan-4,9-diyl)bis(oxy))bis(carbonyl))bis(azanediyl))bis(ethane-2,1-diyl))bis(azanediyl))diacetic acid](/abs-image/US/2022/08/16/US11414394B2/abs.jpg.150x150.jpg)
摘要：
A process for producing a hydrate of a hydrochloride salt of 2,2′-((((((2-acetylnaphtho[2,3-b]furan-4,9-diyl)bis(oxy))bis(carbonyl))bis(azanediyl))bis(ethane-2,1-diyl))bis(azanediyl))diacetic acid of the formula: wherein the process comprises the following step: recrystallizing the hydrochloride salt of 2,2′-((((((2-acetylnaphtho[2,3-b]furan-4,9-diyl)bis(oxy))bis(carbonyl))bis(azanediyl))bis(ethane-2,1-diyl))bis(azanediyl))diacetic acid, in the presence of hydrochloric acid and a recrystallization solvent; wherein the recrystallization solvent is methanol, ethanol, 2-propanol, diethyl ether, ethyl acetate, benzene, toluene, acetone, dichloromethane, chloroform, hexane, dimethylformamide, acetonitrile, or water; or mixed solvent thereof.
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