- 专利标题： High affinity antibodies to human IL-6 receptor
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申请号： US16774945申请日： 2020-01-28
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公开(公告)号： US11370843B2公开(公告)日： 2022-06-28
- 发明人: Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
- 申请人： REGENERON PHARMACEUTICALS, INC.
- 申请人地址： US NY Tarrytown
- 专利权人： REGENERON PHARMACEUTICALS, INC.
- 当前专利权人： REGENERON PHARMACEUTICALS, INC.
- 当前专利权人地址： US NY Tarrytown
- 代理机构： Bozicevic, Field & Francis LLP
- 代理商 Karl Bozicevic
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C12N15/12 ; A61K39/00
摘要：
A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.
公开/授权文献
- US20210009698A1 HIGH AFFINITY ANTIBODIES TO HUMAN IL-6 RECEPTOR 公开/授权日：2021-01-14
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