- 专利标题: Method of treating an allergy with allergen-specific monoclonal antibodies
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申请号: US16471213申请日: 2017-12-15
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公开(公告)号: US11352417B2公开(公告)日: 2022-06-07
- 发明人: Jamie M. Orengo , Namita A. Gandhi , Allen Radin , Ana Kostic , Andrew J. Murphy , George D. Yancopoulos
- 申请人: REGENERON PHARMACEUTICALS, INC.
- 申请人地址: US NY Tarrytown
- 专利权人: REGENERON PHARMACEUTICALS, INC.
- 当前专利权人: REGENERON PHARMACEUTICALS, INC.
- 当前专利权人地址: US NY Tarrytown
- 代理机构: Merchant & Gould P.C.
- 国际申请: PCT/US2017/066838 WO 20171215
- 国际公布: WO2018/118713 WO 20180628
- 主分类号: C07K16/18
- IPC分类号: C07K16/18 ; A61P37/08 ; A61K9/00 ; A61K39/00
摘要:
The present invention provides methods for treating an allergy by administering one or more antibodies that bind specifically to the allergen. In certain embodiments, the antibodies useful for treating an allergen, bind specifically to the cat allergen, Fel d1. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to Fel d1. The antibodies of the invention are useful for binding to the Fel d1 allergen in vivo, thus preventing binding of the Fel d1 allergen to pre-formed IgE on the surface of mast cells or basophils. In doing so, the antibodies act to prevent the release of histamine and other inflammatory mediators from mast cells and/or basophils, thus ameliorating the untoward response to the cat allergen in sensitized individuals.
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