The invention provides a packing box and a method of using the same, comprising a base surface, side surfaces and receiving compartments; wherein the side surfaces and the base surface form first set of folding marks used to fold along the first folding marks and form a space for the packing box; a plurality of holes are opened on the base surface, and the receiving compartments are fixed on the base surface, with the holes used as openings thereof; each receiving compartment is surrounded by a plurality of wall surfaces, the wall surfaces unparallel to the base surface when the receiving compartments are expanded are defined as unparallel wall surfaces, the other wall surfaces are parallel wall surfaces, and a plurality of second folding marks are formed on the unparallel wall surfaces to be used to fold and expand the corresponding wall surfaces; wherein, when the unparallel wall surfaces are folded, the internal cavities of the receiving compartments disappear and the receiving compartments are retracted, and when the unparallel wall surfaces are expanded, the receiving compartments are expanded. The proposal of the invention has advantages that the space occupied by the packing box can be reduced during transportation and storage, the packing box can be formed conveniently and quickly, and the final packing box structure is stable and reliable.