Presented are systems and methods for the accurate acquisition of medical measurement data of a body part of patient. To assist in acquiring accurate medical measurement data, an automated diagnostic and treatment system provides instructions to the patient to allow the patient to precisely position a medical instrument in proximity to a target spot of a body part of patient. For a stethoscope examination, the steps may include utilizing object tracking to determine if the patient has moved the stethoscope to a recording site; utilizing DSP processing to confirm that the stethoscope is in operation, utilizing DSP processing to generate a pre-processed audio sample from a recorded audio signal; using machine learning (ML) to determine if a signal of interest (SOI) is present in the pre-processed sample. If SoI is present, using ML to evaluate characteristics in the signal which indicate the presence of abnormalities in the organ being measured.