A mechanism that dynamically creates a new access policy for a set of database servers when a policy violation has been identified in a database access response issued by any database in the set. The new access policy is then propagated in real-time and instantiated across the set of database servers so as to inoculate the other database servers and pre-empt any new compromise of information based on the intruder's actions that were found to have produced the policy violation in the first instance. Thus, the approach uses a response policy violation at one database server of a set to trigger generation of a new request access policy that is then instantiated across one or more other database servers. This response policy violation-to-request access policy instantiation occurs in substantially real-time so that the intruder cannot use a prior successful access request to obtain information from other databases using a similar strategy.