- 专利标题： Anti-TGF-beta antibodies and their use
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申请号： US16931198申请日： 2020-07-16
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公开(公告)号： US11242384B2公开(公告)日： 2022-02-08
- 发明人: Gary Shapiro , Kevin Brower , Patrick Finn , Richard C. Gregory , Rao Koduri , Feng Liu , Natalia Malkova , Parminder Mankoo , Jack R. Pollard , Huawei Qiu , Joachim Theilhaber , Christopher Winter , Marcella Yu
- 申请人： SANOFI
- 申请人地址： FR Paris
- 专利权人： SANOFI
- 当前专利权人： SANOFI
- 当前专利权人地址： FR Paris
- 代理机构： Steptoe & Johnson LLP
- 代理商 Z. Ying Li; Mauricio Alvarez
- 优先权： EP17305061 20170120
- 主分类号： C07K16/22
- IPC分类号： C07K16/22 ; A61P35/00 ; C07K16/28 ; C07K16/30 ; C07K16/32 ; A61K39/00
摘要：
The invention provides an improved pan-TGF-β antibody for treatment of conditions that are mediated by TGF-β, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.
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