发明授权
- 专利标题: Crystal forms of demethyleneberberine hydrochloride and preparation method therefor
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申请号: US16960810申请日: 2018-07-12
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公开(公告)号: US11242340B2公开(公告)日: 2022-02-08
- 发明人: Yubin Zhang , Yuanqiang Zhang , Miao Zhang , Qingxia Li
- 申请人: China Pharmaceutical University
- 申请人地址: CN Jiangsu
- 专利权人: China Pharmaceutical University
- 当前专利权人: China Pharmaceutical University
- 当前专利权人地址: CN Jiangsu
- 代理机构: Saliwanchik, Lloyd & Eisenschenk
- 优先权: CN201810115491.2 20180206
- 国际申请: PCT/CN2018/095341 WO 20180712
- 国际公布: WO2019/153644 WO 20190815
- 主分类号: C07D455/03
- IPC分类号: C07D455/03 ; A61K31/4745 ; A61P9/10 ; A61P3/06
摘要:
Provided are four crystal forms, A, B, C and D, of demethyleneberberine hydrochloride, and a preparation method therefor, and further provided are X-ray powder diffraction characteristic absorption peaks, infrared absorption peaks and DSC spectra of the four crystal forms. The X-ray powder diffraction characteristic diffraction peaks of the crystal forms are at about 8.205°, 8.805°, 10.817°, 14.835°, 15.479°, 16.668°, 17.492°, 18.529°, 20.656°, 21.536°, 23.538°, 25.657°, 26.192°, and 28.808°. A preparation method for the four crystal forms of the demethyleneberberine hydrochloride is also involved. The preparation method has a simple process, a high yield and a low cost; and has a high product purity and a stable quality.
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