- 专利标题： Oxadiazole linkers and use thereof
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申请号： US16629885申请日： 2018-06-04
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公开(公告)号： US11241503B2公开(公告)日： 2022-02-08
- 发明人: Nianhe Han , Deqiang An , Di Zeng , Baoxiang Wang , Huali Li , Hang Chen , Chun Yang
- 申请人： NewBio Therapeutics, Inc.
- 申请人地址： CN Shanghai
- 专利权人： NewBio Therapeutics, Inc.
- 当前专利权人： NewBio Therapeutics, Inc.
- 当前专利权人地址： CN Shanghai
- 代理机构： Edell, Shapiro & Finnan, LLC
- 优先权： CN201710556847.1 20170710
- 国际申请： PCT/CN2018/089767 WO 20180604
- 国际公布： WO2019/011078 WO 20190117
- 主分类号： A61K47/68
- IPC分类号： A61K47/68 ; C07D271/113 ; C07K16/32
摘要：
The present invention is directed to oxadiazole linkers and use thereof, more specifically to the compounds represented by formula I, II, and III, and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from said oxadiazole linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula I, II, and III is the same as that in the description.
公开/授权文献
- US20210154320A1 OXADIAZOLE LINKERS AND USE THEREOF 公开/授权日：2021-05-27
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