Methods, systems, and apparatus, including computer programs encoded on computer storage media, for managing user interactions with a blockchain. One of the methods includes: receiving a user input in a command line interface (CLI), wherein the user input comprises a reference to one or more configurations; determining, by a command manager based on the user input, a blockchain-related operation and a command plug-in associated with the blockchain-related operation; generating, by the determined command plug-in, a command based on the determined operation and the one or more configurations; and sending, by a software development kit (SDK) associated with the blockchain, the command to one or more nodes associated with the blockchain.