Described herein are systems, architectures, circuits, devices, and methods for a DC-DC converter that dynamically adjusts a supply voltage to a power amplifier based on the number of resource blocks in a signal to be transmitted. The disclosed technologies estimate the number of resource blocks in a signal, generate a signal corresponding to the estimated number of resource blocks, and modify a supply voltage based on the generated signal. These technologies can be used to increase the efficiency of power amplifier systems for cellular signals being transmitted that have fewer resource blocks than is typically assumed (e.g., at least 100 resource blocks).