- 专利标题: Method for manufacturing diastereomer of citric acid derivative
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申请号: US16606376申请日: 2018-04-23
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公开(公告)号: US11155519B2公开(公告)日: 2021-10-26
- 发明人: Katsuya Hiraishi , Hiroyuki Soma , Fumie Jimma , Taro Adachi , Ippei Yamaoka , Naoyuki Endo
- 申请人: OTSUKA PHARMACEUTICAL FACTORY, INC. , ADABIO CO., LTD.
- 申请人地址: JP Tokushima; JP Gunma
- 专利权人: OTSUKA PHARMACEUTICAL FACTORY, INC.,ADABIO CO., LTD.
- 当前专利权人: OTSUKA PHARMACEUTICAL FACTORY, INC.,ADABIO CO., LTD.
- 当前专利权人地址: JP Tokushima; JP Gunma
- 代理机构: Greenblum & Bernstein, P.L.C.
- 优先权: JPJP2017-089725 20170428
- 国际申请: PCT/JP2018/016495 WO 20180423
- 国际公布: WO2018/199040 WO 20181101
- 主分类号: C07D207/416
- IPC分类号: C07D207/416 ; A61P1/16
摘要:
By using ion exchange column chromatography or calcium carbonate to an aqueous solution containing a compound A represented by the following formula and citric acid, citric acid in the aqueous solution is removed and a crystalline compound A is obtained by being thereafter subjected to several steps. Further a high-purity noncrystalline compound A is obtained by using calcium carbonate, sulfuric acid, an organic solvent and the like to the aqueous solution containing the compound A and citric acid to remove citric acid and the crystalline compound A in the solution. The configuration of the crystalline compound A is an SS isomer in the RS notation system. The configuration of the noncrystalline compound A is an SR isomer.
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