- 专利标题: Isoform-selective TGFβ1 inhibitors and use thereof
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申请号: US16509068申请日: 2019-07-11
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公开(公告)号: US11130803B2公开(公告)日: 2021-09-28
- 发明人: Abhishek Datta , Allan Capili , Thomas Schurpf , Constance Martin , Kevin B. Dagbay , Christopher Chapron , Stefan Wawersik , Christopher Littlefield , Gregory J. Carven , Alan Buckler , Susan Lin , Justin W. Jackson , Caitlin Stein , Matthew Salotto , Andrew Avery , Anthony Cooper
- 申请人: Scholar Rock, Inc.
- 申请人地址: US MA Cambridge
- 专利权人: Scholar Rock, Inc.
- 当前专利权人: Scholar Rock, Inc.
- 当前专利权人地址: US MA Cambridge
- 代理机构: McCarter & English, LLP
- 代理商 Marcie B. Clarke
- 主分类号: C07K16/22
- IPC分类号: C07K16/22 ; A61P35/00 ; C07K16/28 ; A61K39/395 ; A61K39/00 ; A61P13/12 ; A61P1/16 ; A61K49/00 ; A61K45/06
摘要:
Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1 with high potency. Related compositions, methods and therapeutic use are also disclosed.
公开/授权文献
- US20200079840A1 ISOFORM-SELECTIVE TGFB1 INHIBITORS AND USE THEREOF 公开/授权日:2020-03-12
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