- 专利标题: Compounds, compositions, and methods for increasing CFTR activity
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申请号: US16510406申请日: 2019-07-12
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公开(公告)号: US11098035B2公开(公告)日: 2021-08-24
- 发明人: Cecilia M. Bastos , Benito Munoz , Bradley Tait
- 申请人: Proteostasis Therapeutics, Inc.
- 申请人地址: US MA Boston
- 专利权人: Proteostasis Therapeutics, Inc.
- 当前专利权人: Proteostasis Therapeutics, Inc.
- 当前专利权人地址: US MA Boston
- 代理机构: Goodwin Procter LLP
- 主分类号: C07D413/12
- IPC分类号: C07D413/12 ; A61K31/42 ; A61K31/4245 ; C07D413/14 ; C07D409/14 ; C07D417/12 ; C07D261/18 ; C07D307/54 ; C07D405/12 ; C07D407/12 ; A61K31/422 ; A61K31/433 ; A61K31/5377 ; A61K45/06 ; C07D307/68 ; G01N33/50
摘要:
The present disclosure is directed to disclosed compounds that increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells.
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