A system can determine properties associated with a plurality of wellbore zones extending radially outward from a wellbore of a drilling operation. The system can determine an operating window for a drilling pressure of the drilling operation based on the properties associated with the plurality of wellbore zones. The system can access real-time data for the plurality of wellbore zones during the drilling operation. The system can determine an adjusted operating window for the drilling pressure based on the real-time data. The system can output a command to adjust, in real time, at least one drilling parameter of the drilling operation based on the adjusted operating window.