A disease diagnosis system including a processor and a storage device for storing a neural network and using a biometric image and the neural network, the disease diagnosis system including a micro-neural network for receiving a first tile included in the biometric image through a first input layer, and including a plurality of first layers and an output layer, and a macro-neural network for receiving a macro-tile including the first tile and at least one or more second tiles adjacent to the first tile through a second input layer, and including a plurality of second layers and the output layer, in which the output layer includes at least one state channel indicating a state of a disease of a biological tissue corresponding to the first tile.