System for synchronization of content between open applications. Remote access server (RAS) provides remote desktop to a mobile device. The mobile device has a remote access client component and communicates with the RAS and with an authorization component. First computer with a host application is connected to the RAS. Second computer is connected to the RAS and has a native application or a VM with a guest application. Authentication component authenticates the mobile device and the computers. The RAS synchronizes data between the mobile device and the computers, and provides a remote desktop for the mobile device via a remote access client component. The remote desktop includes the host application. Data entered in the host application for the first computer on the mobile device appears in the remote desktop via the RAS, and is synchronized with the guest application on the second computer.