- 专利标题： Solid forms of an HPK1 inhibitor
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申请号： US16985526申请日： 2020-08-05
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公开(公告)号： US11066394B2公开(公告)日： 2021-07-20
- 发明人: Zhongjiang Jia , William Frietze
- 申请人： Incyte Corporation
- 申请人地址： US DE Wilmington
- 专利权人： Incyte Corporation
- 当前专利权人： Incyte Corporation
- 当前专利权人地址： US DE Wilmington
- 代理机构： Fish & Richardson P.C.
- 主分类号： C07D403/14
- IPC分类号： C07D403/14 ; C07D403/12
摘要：
The present invention relates to salt forms of the hematopoietic progenitor kinase 1 (HPK 1) inhibitors N-(2-((2S,4S)-4-Amino-2-(hydroxymethyl)pyrrolidin-1-yl)-5-fluorophenyl)-2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxamide and N-(2-((2S,4S)-4-Amino-2-(hydroxymethyl)pyrrolidin-1-yl)-4-(4-cyanopyridin-3-yl)phenyl)-2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxamide, including methods of preparation thereof, where the compounds are useful in the treatment of HPK1 mediated diseases such as cancer.
公开/授权文献
- US20210040071A1 SOLID FORMS OF AN HPK1 INHIBITOR 公开/授权日：2021-02-11
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