- 专利标题: Heterocyclic sulfones as ROR gamma modulators
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申请号: US16341474申请日: 2017-10-12
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公开(公告)号: US10934286B2公开(公告)日: 2021-03-02
- 发明人: Qingjie Liu , T. G. Murali Dhar , Lan-ying Qin , Lyndon A. M. Cornelius , Hai-Yun Xiao , Jianqing Li , Robert J. Cherney
- 申请人: BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址: US NJ Princeton
- 专利权人: BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人: BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人地址: US NJ Princeton
- 代理商 Elliott Korsen
- 国际申请: PCT/US2017/056257 WO 20171012
- 国际公布: WO2018/071620 WO 20180419
- 主分类号: C07D471/04
- IPC分类号: C07D471/04 ; C07D491/147
摘要:
There are described RORγ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ Gamma activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ Gamma activity, for example, autoimmune and/or inflammatory disorders.
公开/授权文献
- US20190300523A1 HETEROCYCLIC SULFONES AS ROR GAMMA MODULATORS 公开/授权日:2019-10-03
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