Processes and multiple-stage catalyst systems are disclosed for producing propene by at least partially isomerizing butene in an isomerization reaction zone having an isomerization catalyst to form an isomerization reaction product, at least partially metathesizing the isomerization reaction product in a metathesis reaction zone having a metathesis catalyst to form a metathesis reaction product, and at least partially cracking the metathesis reaction product in a cracking reaction zone having a cracking catalyst. The isomerization catalyst may be MgO, and the metathesis catalyst may be a mesoporous silica catalyst support impregnated with a metal oxide. The metathesis reaction zone may be downstream of the isomerization reaction zone, and the cracking reaction zone may be downstream of the metathesis reaction zone.