Tunable apodized multiple-focus ophthalmic devices and methods characterized by a lens with multiple optical zones each with an optical power optimized for one or more focal lengths and a tunable apodization mask positioned within at least a portion of the optical zone(s). Upon a desired change of focus for the wearer, an optical transmission characteristic of the tunable apodization mask may be varied. The tunable apodization mask may take the form of an electrochromic device or another suitable material.