Example embodiments disclosed herein relate to audio source separation with source direction determined based on iterative weighted component analysis. A method of separating audio sources in audio content is disclosed. The audio content includes a plurality of channels. The method includes obtaining multiple data samples from multiple time-frequency tiles of the audio content. The method also includes analyzing the data samples to generate multiple components in a plurality of iterations, wherein each of the components indicates a direction with a variance of the data samples, and wherein in each of the plurality of iterations, each of the data samples is weighted with a weight that is determined based on a selected component from the multiple components. The method further includes determining a source direction of the audio content based on the selected component for separating an audio source from the audio content. Corresponding system and computer program product of separating audio sources in audio content are also disclosed.