- 专利标题: Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto
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申请号: US16872812申请日: 2020-05-12
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公开(公告)号: US10927123B2公开(公告)日: 2021-02-23
- 发明人: Thuy-Anh Tran , Quyen-Quyen Do , Brett Ullman , Anthony C. Blackburn , Maiko Nagura
- 申请人: Arena Pharmaceuticals, Inc.
- 申请人地址: US CA San Diego
- 专利权人: Arena Pharmaceuticals, Inc.
- 当前专利权人: Arena Pharmaceuticals, Inc.
- 当前专利权人地址: US CA San Diego
- 代理机构: Fish & Richardson P.C.
- 主分类号: C07D491/107
- IPC分类号: C07D491/107 ; A61P9/04 ; A61P9/10 ; A61K45/06 ; A61K31/4525
摘要:
The present invention relates to compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the beta-3 adrenergic receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of a beta-3 adrenergic receptor-mediated disorder, such as, heart failure; cardiac performance in heart failure; mortality, reinfarction, and/or hospitalization in connection with heart failure; acute heart failure; acute decompensated heart failure; congestive heart failure; severe congestive heart failure; organ damage associated with heart failure (e.g., kidney damage or failure, heart valve problems, heart rhythm problems, and/or liver damage); heart failure due to left ventricular dysfunction; heart failure with normal ejection fraction; cardiovascular mortality following myocardial infarction; cardiovascular mortality in patients with left ventricular failure or left ventricular dysfunction; left ventricular failure; left ventricular dysfunction; class II heart failure using the New York Heart Association (NYHA) classification system; class III heart failure using the New York Heart Association (NYHA) classification system; class IV heart failure using the New York Heart Association (NYHA) classification system; LVEF
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