- 专利标题: Process for preparing intermediate of anti-tumor drug niraparib and intermediate thereof
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申请号: US16755561申请日: 2018-10-12
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公开(公告)号: US10927077B2公开(公告)日: 2021-02-23
- 发明人: Tianhao Wang
- 申请人: ZAI LAB (SHANGHAI) CO., LTD.
- 申请人地址: CN Shanghai
- 专利权人: ZAI LAB (SHANGHAI) CO., LTD.
- 当前专利权人: ZAI LAB (SHANGHAI) CO., LTD.
- 当前专利权人地址: CN Shanghai
- 代理机构: Foley & Lardner LLP
- 优先权: CN201710953949.7 20171013
- 国际申请: PCT/CN2018/110025 WO 20181012
- 国际公布: WO2019/072237 WO 20190418
- 主分类号: C07D211/02
- IPC分类号: C07D211/02 ; C07D211/76
摘要:
Disclosed is a process for preparing an intermediate of anti-tumor drug niraparib and an intermediate thereof. The present invention discloses a process for preparing compound f, which comprises conducting a cyclization reaction of compound e in a solvent and in the presence of a base to give compound f. The process of the present invention does not involve the steps of catalytic reduction or catalytic coupling reaction of precious metals and chiral separation, which has advantages such as low equipment requirements, simple operation, favorable industrial production, avoiding waste liquid containing heavy metals and phosphorus, low cost and high product ee value.
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