A neural device to which a conditioned response function is imparted and a driving method thereof are disclosed. Quantum dots and a polymer insulating layer are formed between upper and lower electrodes. Conductive filaments are formed at interfaces between the quantum dots and the polymer insulating layer. When a positive pulse, which is an unconditioned stimulus signal, is applied, the conductive filaments are formed, and a low resistance state is implemented. As the number of applications of a negative pulse, which is a conditioned stimulus signal, increases, the neural device is switched from a high resistance state to the low resistance state. Through this, the neural device having learning ability for the conditioned stimulus signal may be implemented and driven.