![Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors](/docs/US/2021-01-05/US10881652B2/abs.jpg.600x600.jpg)
- 专利标题： Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
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申请号： US16579150申请日： 2019-09-23
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公开(公告)号： US10881652B2公开(公告)日： 2021-01-05
- 发明人: Steven W. Andrews , Sean Aronow , James F. Blake , Barbara J. Brandhuber , James Collier , Adam Cook , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski , Elizabeth A. McFaddin , Megan L. McKenney , Oren T. McNulty , Andrew T. Metcalf , David A. Moreno , Ginelle A. Ramann , Tony P. Tang , Li Ren , Shane M. Walls
- 申请人： Array Biopharma Inc.
- 申请人地址： US CO Boulder
- 专利权人： Array Biopharma Inc.
- 当前专利权人： Array Biopharma Inc.
- 当前专利权人地址： US CO Boulder
- 代理商 Brad Wayne Crawford
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/4545 ; A61K31/4162 ; A61P1/00 ; A61P35/00 ; A61P35/02 ; A61K31/444 ; A61K31/497 ; A61K31/501 ; A61K31/506 ; A61K31/5377 ; A61K45/06 ; A61P1/12
![Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors](/abs-image/US/2021/01/05/US10881652B2/abs.jpg.150x150.jpg)
摘要：
Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
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