- 专利标题： C3-carbon linked glutarimide degronimers for target protein degradation
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申请号： US16186341申请日： 2018-11-09
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公开(公告)号： US10849982B2公开(公告)日： 2020-12-01
- 发明人: Andrew J. Phillips , Chris G. Nasveschuk , James A. Henderson , Yanke Liang , Minsheng He , Kiel Lazarski , Gesine Kerstin Veits , Harit U. Vora
- 申请人： C4 Therapeutics, Inc.
- 申请人地址： US MA Watertown
- 专利权人： C4 Therapeutics, Inc.
- 当前专利权人： C4 Therapeutics, Inc.
- 当前专利权人地址： US MA Watertown
- 代理机构： Knowles Intellectual Property Strategies, LLC
- 主分类号： A61K47/54
- IPC分类号： A61K47/54 ; A61K31/4545 ; A61K31/506 ; A61K31/519 ; C07D401/14 ; C07D413/04 ; C07D221/22 ; C07D401/12 ; C07D401/06 ; C07D401/04 ; C07D495/04 ; C07D471/08 ; C07D487/04 ; C07D211/86 ; C07D495/14 ; C07D413/14 ; C07D417/14 ; C07D211/90 ; C07D519/00 ; C07D405/14 ; C07D417/04 ; C07D471/04 ; C07D211/88 ; A61K31/45 ; A61K31/451 ; A61K31/454 ; C07K14/47 ; C07K14/72
摘要：
This invention provides Degronimers that have carbon-linked E3 Ubiquitin Ligase targeting moieties (Degrons), which can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.
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