- 专利标题： EGF(A) analogues with fatty acid substituents
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申请号： US16069932申请日： 2017-01-13
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公开(公告)号： US10822385B2公开(公告)日： 2020-11-03
- 发明人: Jianhe Chen , Jesper F. Lau , Janos Tibor Kodra , Birgit Wieczorek , Lars Linderoth , Henning Thoegersen , Salka Elboel Rasmussen , Patrick William Garibay
- 申请人： Novo Nordisk A/S
- 申请人地址： DK Bagsvaerd
- 专利权人： Novo Nordisk A/S
- 当前专利权人： Novo Nordisk A/S
- 当前专利权人地址： DK Bagsvaerd
- 代理商 Jianjie Hu
- 优先权： com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@6e4e8067
- 国际申请： PCT/EP2017/050668 WO 20170113
- 国际公布： WO2017/121850 WO 20170720
- 主分类号： C07K14/485
- IPC分类号： C07K14/485 ; A61K38/17 ; C07K14/705 ; A61K38/00
摘要：
The invention relates to compounds derived from the EGF(A) domain of LDL-R, in particular compounds comprising a peptide analogue of the wild-type EGF(A) (LDL-R(293-332)) sequence and at least one substituent comprising at least one fatty acid group. The invention also relates to a pharmaceutical composition thereof and use a medicament. The novel EGF(A) compounds of the invention are useful as treatment e.g. in the field of cholesterol lowering, dyslipidaemia and cardiovascular disease.
公开/授权文献
- US20190016768A1 EGF(A) ANALOGUES WITH FATTY ACID SUBSTITUENTS 公开/授权日：2019-01-17
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