Invention Grant
- Patent Title: TNF receptor signaling modulator assay
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Application No.: US15736520Application Date: 2015-10-22
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Publication No.: US10705094B2Publication Date: 2020-07-07
- Inventor: James Philip O'Connell , John Robert Porter , Alastair Lawson , Boris Kroeplien , Stephen Edward Rapecki , Timothy John Norman , Graham John Warrellow
- Applicant: UCB Biopharma SRL
- Applicant Address: BE Brussels
- Assignee: UCB BIOPHARMA SRL
- Current Assignee: UCB BIOPHARMA SRL
- Current Assignee Address: BE Brussels
- Agency: Medler Ferro Woodhouse & Mills PLLC
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@51693ead
- International Application: PCT/EP2015/074524 WO 20151022
- International Announcement: WO2016/202413 WO 20161222
- Main IPC: G01N33/68
- IPC: G01N33/68 ; C07K14/525 ; C07K14/705 ; C07K16/24 ; A61K47/64 ; A61P37/00 ; C07D401/14 ; C07D471/00 ; C07D213/72 ; C07D235/04 ; C07D239/26 ; C07D471/04 ; A61P35/00
Abstract:
It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. A new assay for identifying compounds with this mechanism of action is also disclosed.
Public/Granted literature
- US20180172702A1 MODULATOR ASSAY Public/Granted day:2018-06-21
Information query
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