A vehicle control system determines a predicted location of wheel slip for an upcoming trip of a vehicle system by comparing a vehicle characteristic, route characteristic, and/or weather characteristic associated with the upcoming trip with a vehicle characteristic, route characteristic, and/or weather characteristic associated with a previous detection of wheel slip. Movement of the vehicle system is controlled during the upcoming trip by reducing tractive effort generated by a leading vehicle of the vehicle system relative to a trailing vehicle of the vehicle system during movement over the predicted location, reducing tractive effort generated by a leading axle in a vehicle of the vehicle system relative to a trailing axle of the vehicle during movement over the predicted location, and/or directing an adhesion modifying device to automatically dispense an adhesion modifying substance onto the predicted location.