Invention Grant
- Patent Title: System and method for fabrication of uniform polymer films containing nano and micro particles via continuous drying process
-
Application No.: US14777191Application Date: 2014-03-17
-
Publication No.: US10646452B2Publication Date: 2020-05-12
- Inventor: Rajesh N. Dave , Ramani Susarla , Boris Khusid , Anagha A. Bhakay , Ecevit A. Bilgili , Fernando Muzzio
- Applicant: New Jersey Institute of Technology
- Applicant Address: US NJ Newark US NJ New Brunswick
- Assignee: New Jersey Institute of Technology,Rutgers, The State University of New Jersey
- Current Assignee: New Jersey Institute of Technology,Rutgers, The State University of New Jersey
- Current Assignee Address: US NJ Newark US NJ New Brunswick
- Agency: McCarter & English, LLP
- International Application: PCT/US2014/030506 WO 20140317
- International Announcement: WO2014/145699 WO 20140918
- Main IPC: B29C39/14
- IPC: B29C39/14 ; A61K9/70 ; A61K9/00 ; A61K31/216 ; A61K31/343 ; A61K47/32 ; A61K47/38 ; B29C39/00 ; A61F13/00 ; B29L7/00

Abstract:
The present disclosure provides improved stripfilm based pharmaceutical products (e.g., for enhancing dissolution and bioavailability). More particularly, the present disclosure provides improved systems/methods for fabricating stripfilm based pharmaceutical products by utilizing higher viscosity film forming precursors and drying methods that accomplish improved/faster drying and provide improved/excellent content uniformity of active pharmaceutical agents in the stripfilm based pharmaceutical products. Exemplary systems/methods advantageously use high viscosity, bio-compatible polymeric precursors, (optional use of surface modified drug powders), and convective drying for fabrication of thin films loaded with nano and/or micro sized particles of poorly water-soluble active pharmaceutical ingredients (APIs) to achieve improved active content uniformity and very fast dissolution from poorly water soluble actives, while accomplishing fast drying during the fabrication process. The present disclosure provides for the fast drying (e.g., via low temperature forced convection) of biocompatible polymer films loaded with poorly water-soluble drug nano-particles.
Public/Granted literature
Information query