- 专利标题： Cycloalkylamines as monoamine reuptake inhibitors
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申请号： US15836261申请日： 2017-12-08
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公开(公告)号： US10562878B2公开(公告)日： 2020-02-18
- 发明人: Liming Shao , Fengjiang Wang , Scott Christopher Malcolm , Michael Charles Hewitt , Larry R. Bush , Jianguo Ma , Mark A. Varney , Una Campbell , Sharon Rae Engel , Larry Wendell Hardy , Patrick Koch , John E. Campell
- 申请人： Sunovion Pharmaceuticals Inc.
- 申请人地址： US MA Marlborough
- 专利权人： SUNOVION PHARAMCEUTICALS INC.
- 当前专利权人： SUNOVION PHARAMCEUTICALS INC.
- 当前专利权人地址： US MA Marlborough
- 主分类号： C07D333/20
- IPC分类号： C07D333/20 ; C07C211/17 ; C07C211/40 ; C07C215/42 ; C07C215/44 ; C07C217/52 ; C07C217/74 ; C07C323/32 ; C07D207/06 ; C07D207/08 ; C07D211/14 ; C07D265/14 ; C07D277/28 ; C07D295/06 ; C07D307/52 ; C07D317/58 ; C07D317/72 ; C07D319/06 ; C07D491/056 ; C07C211/29 ; C07D211/16
摘要：
The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
公开/授权文献
- US20180230120A1 CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS 公开/授权日：2018-08-16
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