- Patent Title: System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
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Application No.: US12774709Application Date: 2010-05-05
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Publication No.: US10551371B2Publication Date: 2020-02-04
- Inventor: Xiaobo Wang , Wei Ouyang , Nan Li , Biao Xi , Yama A. Abassi , Xiao Xu
- Applicant: Xiaobo Wang , Wei Ouyang , Nan Li , Biao Xi , Yama A. Abassi , Xiao Xu
- Applicant Address: US CA San Diego
- Assignee: ACEA Biosciences, Inc.
- Current Assignee: ACEA Biosciences, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Wagenknecht IP Law Group PC
- Main IPC: G01N33/487
- IPC: G01N33/487

Abstract:
Devices and methods for performing extracellular recording of cells, such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells is provided. An exemplary device includes a nonconductive substrate forming or provided as a base of one or more wells; a recording electrode positioned on the substrate within the well, wherein the recording electrode is accessible to cells when a cell sample is added to the device; and a reference electrode positioned within the well in a cell-free zone, the cell-free zone characterized as free from contact with cells when the cell sample is added to the device, thereby preventing contact between cells and the reference electrode.
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