- 专利标题: Salts of tetracyclines
-
申请号: US15778132申请日: 2016-11-24
-
公开(公告)号: US10543298B2公开(公告)日: 2020-01-28
- 发明人: Luis Sobral , Livia Santana De Arruda , Margarida Figueiredo , Rafael Antunes , Ana Paula Filipe
- 申请人: Hovione Scientia Limited
- 申请人地址: IE Cork
- 专利权人: Hovione Scientia Limited
- 当前专利权人: Hovione Scientia Limited
- 当前专利权人地址: IE Cork
- 代理机构: Conley Rose, P.C.
- 代理商 Rodney B. Carroll
- 优先权: PT108978 20151124
- 国际申请: PCT/GB2016/053695 WO 20161124
- 国际公布: WO2017/089809 WO 20170601
- 主分类号: A61L29/16
- IPC分类号: A61L29/16 ; C07C231/12 ; C07C237/26 ; A61L31/16 ; A61K31/65
摘要:
A tetracycline salt comprising a tetracycline and an organic acid wherein the organic acid is oxalic acid or maleic acid is provided. The tetracycline is preferably doxycycline, minocycline, sancycline, lymecycline, tetracycline or demeclocycline, and preferred salts include oxycycline maleate, minocycline oxalate, tetracycline oxalate, demeclocycline maleate, demeclocycline oxalate, sancycline maleate, lymecycline maleate, or lymecycline oxalate. A pharmaceutical formulation comprising a tetracycline salt according to the invention is also provided, as is a medical device having coated thereon a salt or pharmaceutical formulation according to the invention. A salt of the invention, or a formulation of the invention are also provided for use as medicaments, particularly for use in the treatment or prevention of an inflammation and/or an infection. There is also provided a method of preparing a tetracycline salt, which method comprises reacting a tetracycline base with an excess of an organic acid in a solvent.
公开/授权文献
- US20180344903A1 Salts of Tetracyclines 公开/授权日:2018-12-06
信息查询