- 专利标题: Lentiviral vector for treating hemoglobin disorders
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申请号: US15510014申请日: 2015-08-14
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公开(公告)号: US10543257B2公开(公告)日: 2020-01-28
- 发明人: Naoya Uchida , John F. Tisdale
- 申请人: The United States of America, as represented by the Secretary, Department of Health and Human Services
- 申请人地址: US MD Bethesda
- 专利权人: The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人: The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址: US MD Bethesda
- 代理机构: Leydig, Voit & Mayer, Ltd.
- 国际申请: PCT/US2015/045358 WO 20150814
- 国际公布: WO2016/039933 WO 20160317
- 主分类号: C12N15/86
- IPC分类号: C12N15/86 ; A61K38/42 ; A61K48/00 ; C12N15/11 ; C12N7/00 ; C07K14/805
摘要:
The invention is directed to a more efficient lentiviral vector comprising a nucleic acid sequence encoding a human β-globin protein or a human γ-globin protein, which is oriented from 5′ to 3′ relative to the lentiviral genome. The invention also provides a composition and method utilizing the lentiviral vector.
公开/授权文献
- US20170296630A1 LENTIVIRAL VECTOR FOR TREATING HEMOGLOBIN DISORDERS 公开/授权日:2017-10-19
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