Method, system, and computer program product for simulating the layout and flow of a manufacturing facility. An initial facility layout concept and a baseline input data set are received which define placement and movement of virtual objects within a virtual facility model. At least one of several analyses is performed based on the initial facility layout concept and the baseline input data set. An event flow analysis that outputs timing for movement of the objects from the initial positions may be performed. A geometric flow analysis that outputs interactions between the objects resulting from the movements from the initial positions may be performed. An ergonomic analysis that outputs human postures and motions resulting from interactions with objects may be performed. A simulated flow model for the manufacturing facility is generated. A three-dimensional virtual environment of the simulated flow model is generated and output for display.