- 专利标题： 3.beta-hydroxysteroid dehydrogenase in steroid dependent disease
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申请号： US15712509申请日： 2017-09-22
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公开(公告)号： US10533228B2公开(公告)日： 2020-01-14
- 发明人: Nima Sharifi , Kai-Hsiung Chang
- 申请人： THE CLEVELAND CLINIC FOUNDATION
- 申请人地址： US OH Cleveland
- 专利权人： THE CLEVELAND CLINIC FOUNDATION
- 当前专利权人： THE CLEVELAND CLINIC FOUNDATION
- 当前专利权人地址： US OH Cleveland
- 代理机构： Tarolli, Sundheim, Covell & Tummino LLP
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/574 ; C12Q1/6886 ; A61K31/58 ; A61K31/4166
摘要：
Methods and kits for characterizing a subject having a steroid-dependent disease such as prostate cancer are described. A method of treating a steroid-dependent disease in a subject by obtaining a biological sample from the subject, determining if the HSD3B1(1245C) gene or 3βHSD1(367T) protein is expressed in the biological sample, and providing treatment other than or in addition to steroid ablation to the subject if the HSD3B1(1245C) gene or 3βHSD1(367T) protein is expressed is also described.
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