- 专利标题: Method for producing 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound and intermediate used in the method
-
申请号: US15933804申请日: 2018-03-23
-
公开(公告)号: US10508084B2公开(公告)日: 2019-12-17
- 发明人: Souichirou Kawazoe , Takahiro Akiba , Kiichi Sato , Akio Miyafuji , Kazuyoshi Obitsu , Junji Itoh , Shun Hirasawa , Hiroyuki Koshio
- 申请人: TACURION
- 申请人地址: US NJ Bridgewater
- 专利权人: TACURION
- 当前专利权人: TACURION
- 当前专利权人地址: US NJ Bridgewater
- 代理机构: Foley & Lardner LLP
- 优先权: JP2012-131504 20120611
- 主分类号: C07D223/16
- IPC分类号: C07D223/16 ; C07C311/21 ; C07C51/09 ; C07C51/367 ; C07C67/31 ; C07C303/40 ; C07D301/00
摘要:
The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.
公开/授权文献
信息查询